NAC & Glutathione Are Transforming Aging! New Study

Glycine and NAC Supplements for Aging

In this video, the speaker discusses a new human study that explores the potential benefits of glycine and NAC supplements in improving and reversing age-associated abnormalities. The study focuses on the role of glutathione in promoting health in aging humans.

Background on Oxidants and Antioxidants

• Mitochondria release oxidants that can damage cells.

• Experiments have shown that not all oxidants are bad.

• Oxidants can be stress-induced survival signals that stimulate cells to become more efficient.

• The goal is to balance oxidants and antioxidants to maintain optimal health.

Role of Glutathione

• Glutathione is an antioxidant critical for regulating oxidative stress and immune function.

• Levels of glutathione stay relatively constant until around age 45 when they start to decline rapidly.

• Glycine and NAC are building blocks for glutathione.

Human Study Results

Study Design

• Randomized placebo-controlled study with 24 older adults (ages 61-80) who were overweight, and 12 younger adults.

• Participants took 100mg/kg of both glycine and NAC daily for 16 weeks.

Findings

• Glycine and NAC supplements significantly improved glutathione deficiency in older adults, bringing levels close to those found in younger adults.

• Improved mitochondrial function, physical function, waist circumference, inflammation levels (high sensitivity CRP reduced by 25%).

• No adverse events reported during the study.

Conclusion

The human study suggests that glycine and NAC supplements may improve multiple age-associated abnormalities by correcting glutathione deficiency and improving mitochondrial function. However, the study was highly restrictive, and the findings may not be generalizable to the wider population.

Understanding Glutathione and Supplements

In this section, the speaker discusses the importance of maintaining a balance between oxidants and antioxidants in our cells. They explain how glutathione supplements can directly get into the cells, which can upset the delicate balance between lowering oxidants and avoiding reductive stress.

The Importance of Regulating Glutathione Synthesis

• Each tissue maintains different amounts of glutathione based on its metabolic demands.

• Cells must be able to regulate their own glutathione synthesis to maintain a delicate balance between lowering oxidants and avoiding reductive stress.

• Excess administration of certain supplements can result in accelerated aging due to reductive stress.

• Glycine and neck supplements provide building blocks for glutathione without messing with its regulation.

Promising Study on Glycine and Neck Supplements

• A small study found that glycine and neck supplements did not lower oxidative markers too much in younger adults, avoiding reductive stress.

• Longer-term studies with larger sample sizes are needed to make health decisions for the general public.

• Dose adjustments may be necessary depending on age.

Conclusion

• The speaker plans to take glycine and neck supplements starting at 45 years old, increasing dosage at 55 years old.

• Further research is needed on supplement use. Check out the next video on creatine supplementation.