S3DMediMagic for Histology- Histology of Liver

Liver Cell Structure and Function

Overview of Hepatocytes

• Hepatocytes are the primary cells in the liver, organized into anastomosing plates radiating from the central vein towards the lobule's periphery.

• The spaces between adjacent hepatocyte rows are known as sinusoids, with each liver cell surrounded by these sinusoids on two sides.

Sinusoidal Structure

• Sinusoids are lined with fenestrated endothelium, allowing for efficient exchange of substances.

• The space between hepatocytes and sinusoidal endothelium is called the space of Disse.

Hepatocyte Specializations

• Hepatocytes exhibit three types of surface specialization: sinusoidal surface, canalicular surface, and intercellular surfaces.

• Bile secreted by liver cells enters bile canaliculi, which are spaces formed between adjacent hepatocyte membranes.

Cellular Activity and Composition

• Hepatocytes contain numerous mitochondria and abundant rough/smooth endoplasmic reticulum, indicating high metabolic activity.

• Liver cells store glycogen, lipids, and ions; some hepatocytes also have nuclei.

Other Liver Cells