Andarine (S4) EXPLAINED! - Full SARM Overview (History, Results, and Side Effects)

Introduction

In this section, Russ introduces himself and his Instagram account.

• Russ introduces himself and asks viewers to follow him on Instagram at Russo Lifts.

• He explains that he is taking on the challenge of creating detailed videos for every single compound.

• He invites viewers to comment their personal experiences with compounds in the discussion below.

S4 (Andarine) - Second Generation SARM

In this section, Russ discusses Andarine (S4), a second-generation SARM.

• Andarine was one of the original SARMs to hit the underground market and was very promising in clinical research.

• The goal of S4 was to come up with an androgen that's better than testosterone for longevity purposes, causing fewer side effects on paper in scientific trials than testosterone.

• The clinical trials aimed to prove that sarms like Aks4 will not bind with the prostate but only towards skeletal muscle and bone.

Benefits of SARMS

In this section, Russ talks about the benefits of SARMS.

• The benefits of SARMS are selective towards skeletal muscle in bone in a certain dosage rate.

• As dosage goes higher in bodybuilding dosages, they're not as selective as some people make them out to be.

Prostate Binding

In this section, Russ discusses prostate binding.

• S4 does not bind with the prostate nearly as much as testosterone.

• The goal of using sarms like Aks4 is to prove with scientific research that they will not bind with the prostate and will only bind towards skeletal muscle and bone.

Clinical Trials

In this section, Russ talks about clinical trials.

• There was a trial where men on testosterone replacement therapy had enlarged prostates. The goal was to replace some of it with S4 which resulted in a lower psa overall meaning their prostate was shrinking while they were overall maintaining the same amount of androgen in the body.

• They found that patients who replaced some of their testosterone dose with S4 had better fat loss effects, more muscle density impact, and the same muscle hypertrophy as far as holding onto their muscle mass rate.

SARMs and Androgen Replacement Therapy

In this section, the speaker discusses the appeal of SARMs for people who are not bodybuilders but rather biohackers. He also talks about the development of S4 (Andarine) and its potential as a future treatment for androgen replacement therapy.

The Appeal of SARMs

• SARMs are appealing to people who are not extreme bodybuilders but rather biohackers.

• They provide a boost without impacting biomarkers to an extreme degree.

Development of S4 (Andarine)

• S4 is recommended because of its attributes on paper.

• It is a second-generation SARM that showed promise in clinical trials.

• It was developed with the pressure of making something that works and could be the future of androgen replacement therapy.

• It has potential as a treatment for osteoporosis in older adults.

Understanding S4

• S4 is a partial agonist to the androgen receptors, which means it does not impact the prostate whatsoever.

• It does not have any estrogen conversion or DHT conversion.

• If stacking with full agonist androgens, they will boot off s4 from receptors.

• High dosages can lead to suppression of natural testosterone levels.

Using S4 Safely

• Some individuals use birth control tablets as an exogenous estrogen source when using high dosages of s4 only cycle.

• Alec did an experiment where he used birth control tablets as an exogenous estrogen control while taking high dosages of s4 only cycle.

S4 Androgen Receptor Modulator

In this section, the speaker discusses the effects of S4 androgen receptor modulator on eyesight, dosage, and sex hormone binding globulin.

Effects on Eyesight

• S4 binds to androgen receptors in the eyes causing fluctuations that can lead to significant eyesight issues.

• High dosages of S4 can cause yellow or green tint vision which can be dangerous while driving at night.

• The eye damage caused by S4 is not permanent but only happens when the half-life of S4 is active in your system.

Dosage

• It's best to split up 25 to 200 milligrams a day every six hours to keep it as stable as possible.

• In higher dosages, cholesterol levels are skewed and sex hormone binding globulin (SHBG) crashes.

Effects on Sex Hormone Binding Globulin

• SHBG does not recognize S4 for what it is; hence it doesn't transport it around. It crashes SHBG leading to low transportation of natural testosterone.

• Keep SHBG on the lower end of normal since one of the main side effects of high enough dosage is crashing SHBG.

Women and PD's

• S4 has no masculinization side effects like deepening voice, hair loss, or body hair growth. Girls have had success with significant dosages besides the eyesight issue.

S4 for Women

In this section, the speaker talks about his experience with women experimenting with their bodies and recommends S4 as a safe option.

Benefits of S4 for Women

• S4 gives women a faster metabolism, increases body mass, cuts them up, makes them look drier, denser and more vascular.

• It helps in a contest prep scenario where they're trying to get really hard and lean and to hold on to their muscle in those critical stages of the final weeks of prep.

Injectable S4

• The speaker shares his experience with injectable s4 which was overkill.

• Alec legit went blind for like a day or two when he was injecting his normal oral dosage blast like he got crazy with it and he literally said he just saw green all day like he could still make stuff out but everything was green it was unbearable he couldn't drive and he had to wait it out for it to half-life out everything went back to normal.

• The speaker believes that injectable administration is not worth it as the hepatoxicity profile of it is very low compared to other androgens especially something alkylated methylation steroids right.

Side Effects of S4

• Overall stone androgen at the end of the day it's still going to skew your good cholesterol so it's going to lower your hdl most likely raise your ldl so unless you're on top of maintaining good cholesterol you should keep that in mind.

• As far as s4 is concerned, this is one of the safest most tried around the world second-generation but it's still got that sketch vibe of being a second generation with it binding to the ar in the eyes.

Muscle Building and Bodybuilding

• As far as a muscle builder bodybuilding type thing in a high enough dosage you can achieve a winstrol type look and you're not going to face hair loss that's a giant key factor for a lot of people especially people prone to male pattern bonus right one cycle of winstrol could take out thousands of hair follicles that you will not get back so think of it that way.

• The speaker thinks S4 needs to be dosed super high in a bodybuilding standpoint to get the benefits out of it.

Conclusion

In this section, the speaker concludes his talk by asking viewers to share his video and subscribe.

• The speaker asks viewers to share his video and subscribe.