Spironolactone - Mechanism of action

Spironolactone Mechanism of Action

Overview of Spironolactone

• Spironolactone is identified as a prodrug that requires metabolism to become active.

• The active metabolite, canrenone, plays a crucial role in the drug's function.

Mechanism of Action

• Canrenone competitively blocks the binding of aldosterone to mineralocorticoid receptors located in the collecting duct cells of the nephron.

• This inhibition reduces receptor activity, leading to decreased expression of genes responsible for sodium channel proteins.